What symptom is most likely to be anticipated in a patient suspected of having pancreatic cancer?

Patients with pancreatic cancer often present with mid-epigastric pain that can radiate to the back. This type of pain is typically due to the tumor's influence on surrounding structures and the irritation of visceral nerves associated with the compromised pancreas. The unique anatomical position of the pancreas and the nerves in its proximity often lead to pain that is not only centered in the abdomen but also manifests in the back.

The characteristic nature of this pain is also relevant for establishing a suspicion of pancreatic pathology, as it may be accompanied by other symptoms such as weight loss, changes in appetite, or jaundice, particularly as the disease progresses and affects adjacent organs.

In contrast, while a large palpable abdominal mass may occur in advanced cases, it is not a common presenting symptom in early pancreatic cancer. Similarly, Cullen’s sign, which indicates intra-abdominal bleeding, and psoas signs are more commonly associated with other conditions like ruptured ectopic pregnancy or appendicitis rather than pancreatic cancer. This focus on the specific type of pain associated with pancreatic cancer helps differentiate it from other potential abdominal issues.