What is one important consideration when prescribing medication to older adults?

When prescribing medication to older adults, one of the most significant considerations is their increased sensitivity to drug effects. As individuals age, physiological changes can affect how drugs are absorbed, distributed, metabolized, and excreted in the body. Older adults may experience altered pharmacokinetics, leading to a greater sensitivity to certain medications, which can result in enhanced effects or increased risk for adverse reactions.

For example, reduced renal function often seen in the elderly can lead to prolonged drug elimination half-lives, potentially resulting in higher plasma concentrations of the drug. Additionally, the aging process may affect receptor sensitivity and the overall response to medications. Therefore, it's crucial to closely monitor older adults after prescribing to adjust dosages or medication regimens as necessary to avoid complications.

Other factors, such as fluid intake or changes in metabolism, can influence medication efficacy, but the heightened sensitivity is paramount because it directly impacts safety and treatment outcomes. Being aware of this increased sensitivity allows healthcare providers to tailor prescriptions for older patients, ensuring both efficacy and safety.